Insulin resistance (HOMA-IR) after curcumin extract intervention showed statistical significance after 6 months and after 9 months: p<0.05 and p<0.01.Ĭurcumin has shown the confident results to be effective for the treatment of impaired glucose tolerance. Also, glycosylated haemoglobin levels A1c (HbA1c) values after curcumin extract intervention showed statistical significance after 3, 6 and 9 months: p<0.01. The two-hour fasting plasma glucose after the curcumin extract intervention showed statistical significance after 3, 6 and 9 months: p<0.01. Most studies were highly biased as data were incomplete or reporting was selective. The Cochrane tool of risk of Bias Tool was used. Two authors independently extracted data and evaluated bias. The diagnosis was determined by fasting plasma glucose values after two-hour oral glucose tolerance testing (OGTT). We included randomized controlled trials (RCTs) with a minimum follow-up period of 6 weeks. The objective of this systematic review was to assess available scientific data on the efficacy and safety of medicinal food plants for the treatment of impaired glucose tolerance. Short-term turmeric supplementation can attenuate proteinuria, TGF-β and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as a safe adjuvant therapy for these patients. No adverse effects related to turmeric supplementation were observed during the trial. Serum levels of TGF-β and IL-8 and urinary protein excretion and IL-8 decreased significantly comparing the pre- and post-turmeric supplementation values. The control group received three capsules identical in colour and size containing starch for the same 2 months.
#Studybox snec trial
Each patient in the trial group received one capsule with each meal containing 500 mg turmeric, of which 22.1 mg was the active ingredient curcumin (three capsules daily) for 2 months.
![studybox snec studybox snec](https://i0.wp.com/net-eco-service.com/wp-content/uploads/2018/11/study-box_1.jpg)
Therefore, this study investigated the effects of turmeric on serum and urinary TGF-β, interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α), as well as proteinuria, in patients with overt type 2 diabetic nephropathy.Ī randomized, double-blind and placebo-controlled study was carried out in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences on 40 patients with overt type 2 diabetic nephropathy, randomized into a trial group (n = 20) and a control group (n = 20). Experimental studies indicate that turmeric improves diabetic nephropathy by suppressing TGF-β. Both proteinuria and transforming growth factor-β (TGF-β) may contribute to the development of ESRD in patients with diabetic nephropathy. End-stage renal disease (ESRD) due to type 2 diabetic nephropathy is a very common condition which is increasing in prevalence, and is associated with high global levels of mortality and morbidity.